1. In a large bowl, combine the ground beef with the Cajun seasoning, garlic powder, onion powder, and a light sprinkle of salt and pepper. Mix gently to combine, being careful not to overwork the meat. Divide the mixture into 4 equal portions and shape them into burger patties, pressing a slight indentation in the center of each to help them cook evenly.

2. Now, it’s time to fire up the grill or smoker. Preheat your grill to medium-high heat or heat a cast iron skillet over medium heat. Add a bit of oil or butter to the surface to prevent sticking and enhance the browning.

3. Place the patties on the grill or in the skillet and cook for about 4-5 minutes on the first side, without pressing down, to allow a nice crust to form. Flip the patties and cook for another 3-4 minutes on the other side, or until they reach your desired level of doneness (160°F/71°C for well-done). During the last minute of cooking, top each patty with a slice of cheese and cover loosely to help it melt.

4. While the burgers are cooking, take a moment to lightly butter the buns and toast them on the grill or in the skillet until golden brown. This simple step adds incredible flavor and helps prevent sogginess from the sauces and toppings.

5. Now, it’s time to bring everything together and create a masterpiece. Start by spreading your choice of spicy mayo, remoulade, or chipotle aioli on the bottom bun. Place the cheesy, Cajun-seasoned patty on top, followed by crisp lettuce, juicy tomato slices, tangy pickles, and zesty red onion. If you’re feeling extra adventurous, add a few slices of jalapeño or a few dashes of hot sauce for an added kick.

6. Cap it off with the top bun and press gently to hold everything in place. Get ready for a flavor explosion in every bite!